Cell Renewal and Regeneration

Collagen VI regulates satellite cell self-renewal and muscle regeneration

Adult muscle stem cells, or satellite cells have essential roles in homeostasis and regeneration of skeletal muscles. Satellite cells are located within a niche that includes myofibers and extracellular matrix. The function of specific extracellular matrix molecules in regulating SCs is poorly understood. Here, we show that the extracellular matrix protein collagen VI is a key component of the ...

-Cell Regeneration in the Adult Pancreas: Self-Renewal Versus Neogenesis

Investigation of Urban Renewal and Regeneration Management Policy Changes in City of Tehran (Between 1990-2014)

Urban regeneration and renewal is one of the urban development subjects that have undergone substantial changes in last decades in its approaches and also management process. Despite these global changes, policy making in this field of urban development have been delayed in Iran. In the last three decades, the spread of distressed urban areas in Tehran and their vulnerability against earthquake...

Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration

Satellite cells (SCs) are stem cells that mediate skeletal muscle growth and regeneration. Here, we observe that adult quiescent SCs and their activated descendants expressed the homeodomain transcription factor Six1. Genetic disruption of Six1 specifically in adult SCs impaired myogenic cell differentiation, impaired myofiber repair during regeneration, and perturbed homeostasis of the stem ce...

Cyclin D2 is sufficient to drive β cell self-renewal and regeneration

Diabetes results from an inadequate mass of functional β cells, due to either β cell loss caused by autoimmune destruction (type I diabetes) or β cell failure in response to insulin resistance (type II diabetes). Elucidating the mechanisms that regulate β cell mass may be key to developing new techniques that foster β cell regeneration as a cellular therapy to treat diabetes. While previous stu...